Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

[Image: see text] Stapled helix peptides can serve as useful tools for inhibiting protein–protein interactions but can be difficult to optimize for affinity. Here we describe the discovery and optimization of a stapled helix peptide that binds to the N-terminal domain of the 70 kDa subunit of replic...

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Detalhes bibliográficos
Main Authors: Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969094/
https://ncbi.nlm.nih.gov/pubmed/24491171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401730y
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