Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

Por Huang, Qiulong, Petros, Andrew M., Virgin, Herbert W., Fesik, Stephen W., Olejniczak, Edward T.
Publicado em 2002

Structural analysis of UBL5, a novel ubiquitin-like modifier

Por McNally, Teresa, Huang, Qiulong, Janis, Richard S., Liu, Zhihong, Olejniczak, Edward T., Reilly, Regina M.
Publicado em 2003

A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand

Por Sun, Qi, Phan, Jason, Friberg, Anders R., Camper, DeMarco V., Olejniczak, Edward T., Fesik, Stephen W.
Publicado no J Biomol NMR (2014)

Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae

Por Yu, Liping, Mack, Jamey, Hajduk, Philip J., Kakavas, Steve J., Saiki, Anne Y.C., Lerner, Claude G., Olejniczak, Edward T.
Publicado em 2003

Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin

Por Yu, Liping, Sun, Chaohong, Mendoza, Renaldo, Wang, Jie, Matayoshi, Edmund D., Hebert, Eric, Pereda-Lopez, Ana, Hajduk, Philip J., Olejniczak, Edward T.
Publicado em 2007

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

Por Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Publicado em 2012

Solution structure of the cytohesin-1 (B2–1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1

Por Betz, Stephen F., Schnuchel, Arndt, Wang, Hong, Olejniczak, Edward T., Meadows, Robert P., Lipsky, Brian P., Harris, Edith A. S., Staunton, Donald E., Fesik, Stephen W.
Publicado em 1998

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

Por Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, Liang, Heng, Harris, Edith A. S., Lupher, Mark L., Wilson, Amy E., Fesik, Stephen W., Staunton, Donald E.
Publicado em 2000

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of Replication Protein A

Por Souza-Fagundes, Elaine M., Frank, Andreas O., Feldkamp, Michael D., Dorset, Daniel C., Chazin, Walter J., Rossanese, Olivia W., Olejniczak, Edward T., Fesik, Stephen W.
Publicado em 2011

A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo

Por Loh, Joy, Huang, Qiulong, Petros, Andrew M, Nettesheim, David, van Dyk, Linda F., Labrada, Lucia, Speck, Samuel H, Levine, Beth, Olejniczak, Edward T, Virgin, Herbert W.
Publicado em 2005

Discovery of potent myeloid cell leukemia 1 (Mcl 1) inhibitors using fragment based methods and structure based design

Por Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P., Garcia-Barrantes, Pedro M., Camper, DeMarco, Chauder, Brian A., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Publicado em 2012

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Por Burns, Michael C., Sun, Qi, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Publicado em 2014

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

Por Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado em 2014

Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design

Por Burke, Jason P., Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M., Belmar, Johannes, Browning, Carrie F., Vigil, Dominico, Friberg, Anders, Camper, DeMarco V., Rossanese, Olivia W., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Publicado no J Med Chem (2015)

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-R(S)

Por Sun, Chaohong, Song, Danying, Davis-Taber, Rachel A., Barrett, Leo W., Scott, Victoria E., Richardson, Paul L., Pereda-Lopez, Ana, Uchic, Marie E., Solomon, Larry R., Lake, Marc R., Walter, Karl A., Hajduk, Philip J., Olejniczak, Edward T.
Publicado em 2007

Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods

Por Pelz, Nicholas F., Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C., Belmar, Johannes, Gregg, Claire, Camper, DeMarco V., Goodwin, Craig M., Arnold, Allison L., Sensintaffar, John L., Friberg, Anders, Rossanese, Olivia W., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Publicado no J Med Chem (2016)

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Por Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.
Publicado no Mol Cell (2015)

Identification and Optimization of Anthranilic Acid-Based Inhibitors of Replication Protein A

Por Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Publicado no ChemMedChem (2016)

Discovery and Biological Characterization of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors

Por Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.
Publicado no FEBS Lett (2016)