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A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand
K-Ras is a well-validated cancer target but is considered to be “undruggable” due to the lack of suitable binding pockets. We previously discovered small molecules that bind weakly to K-Ras but wanted to improve their binding affinities by identifying ligands that bind near our initial hits that we...
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| Publicado no: | J Biomol NMR |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358732/ https://ncbi.nlm.nih.gov/pubmed/25087006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-014-9849-8 |
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