Učitavanje...
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling
K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although directly targeting RAS has proven to be challenging, it may be possible to...
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| Izdano u: | Anal Biochem |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935105/ https://ncbi.nlm.nih.gov/pubmed/29444450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2018.01.025 |
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