Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS

[Image: see text] Proteins in the RAS family are important regulators of cellular signaling and, when mutated, can drive cancer pathogenesis. Despite considerable effort over the last 30 years, RAS proteins have proven to be recalcitrant therapeutic targets. One approach for modulating RAS signaling...

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Bibliografische gegevens
Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Abbott, Jason R., Patel, Pratiq A., Howes, Jennifer E., Akan, Denis T., Kennedy, J. Phillip, Burns, Michael C., Browning, Carrie F., Sun, Qi, Rossanese, Olivia W., Phan, Jason, Waterson, Alex G., Fesik, Stephen W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142059/
https://ncbi.nlm.nih.gov/pubmed/30258545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00296
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