Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes. Aberrant RAS activity is involved in ~30% of all human cancers; hence, SOS1 is an...

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Publicado no:J Med Chem
Main Authors: Hodges, Timothy R., Abbott, Jason R., Little, Andrew J., Sarkar, Dhruba, Salovich, James M., Howes, Jennifer E., Akan, Denis T., Sai, Jiqing, Arnold, Allison L., Browning, Carrie, Burns, Michael C., Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A., Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W., Phan, Jason, Waterson, Alex G., McConnell, Darryl B., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314423/
https://ncbi.nlm.nih.gov/pubmed/30205005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01108
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