Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

Antzeko izenburuak

• Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
  nork: Burns, Michael C., et al.
  Argitaratua: (2014)
• High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling
  nork: Burns, Michael C., et al.
  Argitaratua: (2018)
• Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
  nork: Abbott, Jason R., et al.
  Argitaratua: (2018)
• Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
  nork: Hodges, Timothy R., et al.
  Argitaratua: (2018)
• A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand
  nork: Sun, Qi, et al.
  Argitaratua: (2014)