Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design

Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family of proteins that is overexpressed and amplified in many cancers. Overexpression of Mcl-1 allows cancer cells to evade apoptosis and contributes to the resistance of cancer cells to be effectively treated with various che...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Burke, Jason P., Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M., Belmar, Johannes, Browning, Carrie F., Vigil, Dominico, Friberg, Anders, Camper, DeMarco V., Rossanese, Olivia W., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565203/
https://ncbi.nlm.nih.gov/pubmed/25844895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501984f
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