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Small molecule Mcl-1 inhibitors for the treatment of cancer

The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to se...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Pharmacol Ther
Päätekijät: Belmar, Johannes, Fesik, Stephen W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340597/
https://ncbi.nlm.nih.gov/pubmed/25172548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.08.003
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