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Small molecule Mcl-1 inhibitors for the treatment of cancer
The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to se...
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| Udgivet i: | Pharmacol Ther |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340597/ https://ncbi.nlm.nih.gov/pubmed/25172548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.08.003 |
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