A Surface Groove Essential for Viral Bcl-2 Function During Chronic Infection In Vivo

Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface. We investigated the physiological importance of the BH3 binding groove of an antiapoptotic Bcl-2 protein in...

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Autores principales: Loh, Joy, Huang, Qiulong, Petros, Andrew M, Nettesheim, David, van Dyk, Linda F., Labrada, Lucia, Speck, Samuel H, Levine, Beth, Olejniczak, Edward T, Virgin, Herbert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1238745/
https://ncbi.nlm.nih.gov/pubmed/16201011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0010010
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