Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC with its obligate partner, MAX. Here, we show that br...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427524/
https://ncbi.nlm.nih.gov/pubmed/25818646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.028
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