Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated anticancer target, but efforts to pharmacolog...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
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PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911241/
https://ncbi.nlm.nih.gov/pubmed/31767764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910391116
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