Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

ανά King, Alastair J., Arnone, Marc R., Bleam, Maureen R., Moss, Katherine G., Yang, Jingsong, Fedorowicz, Kelly E., Smitheman, Kimberly N., Erhardt, Joseph A., Hughes-Earle, Angela, Kane-Carson, Laurie S., Sinnamon, Robert H., Qi, Hongwei, Rheault, Tara R., Uehling, David E., Laquerre, Sylvie G.
Έκδοση 2013

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

ανά Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.
Έκδοση 2013

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

ανά Abe, Hiroyuki, Kikuchi, Shinichi, Hayakawa, Kazuhide, Iida, Tetsuya, Nagahashi, Noboru, Maeda, Katsuya, Sakamoto, Johei, Matsumoto, Noriaki, Miura, Tomoya, Matsumura, Koji, Seki, Noriyoshi, Inaba, Takashi, Kawasaki, Hisashi, Yamaguchi, Takayuki, Kakefuda, Reina, Nanayama, Toyomichi, Kurachi, Hironori, Hori, Yoshikazu, Yoshida, Takayuki, Kakegawa, Junya, Watanabe, Yoshihiro, Gilmartin, Aidan G., Richter, Mark C., Moss, Katherine G., Laquerre, Sylvie G.
Έκδοση 2011