Dabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin Lesions

Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma, colorectal carcinoma, ovarian cancer, papillary t...

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Detalhes bibliográficos
Main Authors: King, Alastair J., Arnone, Marc R., Bleam, Maureen R., Moss, Katherine G., Yang, Jingsong, Fedorowicz, Kelly E., Smitheman, Kimberly N., Erhardt, Joseph A., Hughes-Earle, Angela, Kane-Carson, Laurie S., Sinnamon, Robert H., Qi, Hongwei, Rheault, Tara R., Uehling, David E., Laquerre, Sylvie G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701070/
https://ncbi.nlm.nih.gov/pubmed/23844038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067583
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