DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

BACKGROUND: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to i...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Kanu, Nnennaya, Cerone, Maria Antonietta, Goh, Gerald, Zalmas, Lykourgos-Panagiotis, Bartkova, Jirina, Dietzen, Michelle, McGranahan, Nicholas, Rogers, Rebecca, Law, Emily K., Gromova, Irina, Kschischo, Maik, Walton, Michael I., Rossanese, Olivia W., Bartek, Jiri, Harris, Reuben S., Venkatesan, Subramanian, Swanton, Charles
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025597/
https://ncbi.nlm.nih.gov/pubmed/27634334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1042-9
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