Crystal structure of truncated human βB1-crystallin

Por van Montfort, Rob L.M., Bateman, Orval A., Lubsen, Nicolette H., Slingsby, Christine
Publicado em 2003

Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors

Por Langdon, Sarah R., Westwood, Isaac M., van Montfort, Rob L. M., Brown, Nathan, Blagg, Julian
Publicado em 2013

Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction

Por Rankin, Stuart S., Caldwell, John J., Cronin, Nora B., van Montfort, Rob L. M., Collins, Ian
Publicado no European J Org Chem (2016)

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56

Por Pettinger, Jonathan, Le Bihan, Yann‐Vaï, Widya, Marcella, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.
Publicado no Angew Chem Int Ed Engl (2017)

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Por Westwood, Isaac, Cheary, Donna-Marie, Baxter, Joanne E., Richards, Mark W., van Montfort, Rob L.M., Fry, Andrew M., Bayliss, Richard
Publicado em 2009

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Por Matijssen, Cornelis, Silva-Santisteban, M. Cris, Westwood, Isaac M., Siddique, Samerene, Choi, Vanessa, Sheldrake, Peter, van Montfort, Rob L.M., Blagg, Julian
Publicado em 2012

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70

Por Cheeseman, Matthew D., Westwood, Isaac M., Barbeau, Olivier, Rowlands, Martin, Dobson, Sarah, Jones, Alan M., Jeganathan, Fiona, Burke, Rosemary, Kadi, Nadia, Workman, Paul, Collins, Ian, van Montfort, Rob L. M., Jones, Keith
Publicado no J Med Chem (2016)

Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization

Por Whelligan, Daniel K., Solanki, Savade, Taylor, Dawn, Thomson, Douglas W., Cheung, Kwai-Ming J., Boxall, Kathy, Mas-Droux, Corine, Barillari, Caterina, Burns, Samantha, Grummitt, Charles G., Collins, Ian, van Montfort, Rob L. M., Aherne, G. Wynne, Bayliss, Richard, Hoelder, Swen
Publicado em 2010

Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

Por Silva-Santisteban, M. Cris, Westwood, Isaac M., Boxall, Kathy, Brown, Nathan, Peacock, Sam, McAndrew, Craig, Barrie, Elaine, Richards, Meirion, Mirza, Amin, Oliver, Antony W., Burke, Rosemary, Hoelder, Swen, Jones, Keith, Aherne, G. Wynne, Blagg, Julian, Collins, Ian, Garrett, Michelle D., van Montfort, Rob L. M.
Publicado em 2013

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

Por Jones, Alan M., Westwood, Isaac M., Osborne, James D., Matthews, Thomas P., Cheeseman, Matthew D., Rowlands, Martin G., Jeganathan, Fiona, Burke, Rosemary, Lee, Diane, Kadi, Nadia, Liu, Manjuan, Richards, Meirion, McAndrew, Craig, Yahya, Norhakim, Dobson, Sarah E., Jones, Keith, Workman, Paul, Collins, Ian, van Montfort, Rob L. M.
Publicado no Sci Rep (2016)

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

Por Couty, Sylvain, Westwood, Isaac M., Kalusa, Andrew, Cano, Celine, Travers, Jon, Boxall, Kathy, Chow, Chiau Ling, Burns, Sam, Schmitt, Jessica, Pickard, Lisa, Barillari, Caterina, McAndrew, P. Craig, Clarke, Paul A., Linardopoulos, Spiros, Griffin, Roger J., Aherne, G. Wynne, Raynaud, Florence I., Workman, Paul, Jones, Keith, van Montfort, Rob L.M.
Publicado em 2013

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

Por Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros
Publicado no Br J Cancer (2017)

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Por Naud, Sébastien, Westwood, Isaac M., Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J., Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A., Raynaud, Florence I., Linardopoulos, Spiros, van Montfort, Rob L. M., Blagg, Julian
Publicado em 2013

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

Por Reader, John C., Matthews, Thomas P., Klair, Suki, Cheung, Kwai-Ming J., Scanlon, Jane, Proisy, Nicolas, Addison, Glynn, Ellard, John, Piton, Nelly, Taylor, Suzanne, Cherry, Michael, Fisher, Martin, Boxall, Kathy, Burns, Samantha, Walton, Michael I., Westwood, Isaac M., Hayes, Angela, Eve, Paul, Valenti, Melanie, de Haven Brandon, Alexis, Box, Gary, van Montfort, Rob L. M., Williams, David H., Aherne, G. Wynne, Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian
Publicado em 2011

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Por Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian
Publicado no J Med Chem (2016)