Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift assay, followed by X-ray crystallography, identified a...

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Detalhes bibliográficos
Main Authors: Silva-Santisteban, M. Cris, Westwood, Isaac M., Boxall, Kathy, Brown, Nathan, Peacock, Sam, McAndrew, Craig, Barrie, Elaine, Richards, Meirion, Mirza, Amin, Oliver, Antony W., Burke, Rosemary, Hoelder, Swen, Jones, Keith, Aherne, G. Wynne, Blagg, Julian, Collins, Ian, Garrett, Michelle D., van Montfort, Rob L. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680490/
https://ncbi.nlm.nih.gov/pubmed/23776527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065689
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