Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

[Image: see text] APOBEC3B (A3B) deamination activity on ssDNA is considered a contributing factor to tumor heterogeneity and drug resistance in a number of human cancers. Despite its clinical impact, little is known about A3B ssDNA substrate preference. We have used nuclear magnetic resonance to mo...

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Publicat a:ACS Chem Biol
Autors principals: Liu, Manjuan, Mallinger, Aurélie, Tortorici, Marcello, Newbatt, Yvette, Richards, Meirion, Mirza, Amin, van Montfort, Rob L. M., Burke, Rosemary, Blagg, Julian, Kaserer, Teresa
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430498/
https://ncbi.nlm.nih.gov/pubmed/30130388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00639
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