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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase
The Nek family of serine/threonine kinases regulates centrosome and cilia function; in addition, several of its members are potential targets for drug discovery. Nek2 is dimeric, is cell cycle regulated and functions in the separation of centrosomes at G2/M. Here, we report the crystal structures of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2741569/ https://ncbi.nlm.nih.gov/pubmed/19124027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.12.033 |
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