A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

The heat shock protein 70s (HSP70s) are molecular chaperones implicated in many cancers and of significant interest as targets for novel cancer therapies. Several HSP70 inhibitors have been reported, but because the majority have poor physicochemical properties and for many the exact mode of action...

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Publicado no:Sci Rep
Main Authors: Jones, Alan M., Westwood, Isaac M., Osborne, James D., Matthews, Thomas P., Cheeseman, Matthew D., Rowlands, Martin G., Jeganathan, Fiona, Burke, Rosemary, Lee, Diane, Kadi, Nadia, Liu, Manjuan, Richards, Meirion, McAndrew, Craig, Yahya, Norhakim, Dobson, Sarah E., Jones, Keith, Workman, Paul, Collins, Ian, van Montfort, Rob L. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052559/
https://ncbi.nlm.nih.gov/pubmed/27708405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34701
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