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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine‐56
The stress‐inducible molecular chaperone, HSP72, is an important therapeutic target in oncology, but inhibiting this protein with small molecules has proven particularly challenging. Validating HSP72 inhibitors in cells is difficult owing to competition with the high affinity and abundance of its en...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412842/ https://ncbi.nlm.nih.gov/pubmed/28225177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201611907 |
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