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Unexpected Trypsin Cleavage at Ubiquitinated Lysines

[Image: see text] Unexpected tryptic cleavage has been characterized at modified K48 residues in polyubiquitins. In particular, the tryptic products of all seven of the lysine-linked dimers of ubiquitin and of three trimers—linear Ub–(48)Ub–(48)Ub, linear Ub–(63)Ub–(63)Ub, and the branched trimer [U...

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Detalles Bibliográficos
Publicado en:Anal Chem
Main Authors: Burke, Meghan C., Wang, Yan, Lee, Amanda E., Dixon, Emma Kimm, Castaneda, Carlos A., Fushman, David, Fenselau, Catherine
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599693/
https://ncbi.nlm.nih.gov/pubmed/26182167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b01960
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