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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
[Image: see text] Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment screening, but such electrophil...
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| Izdano u: | J Am Chem Soc |
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| Glavni autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2019
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556873/ https://ncbi.nlm.nih.gov/pubmed/31060360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02822 |
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