The potential of 12/15-lipoxygenase inhibitors in stroke therapy

Por van Leyen, Klaus, Holman, Theodore R, Maloney, David J
Publicado no Future Med Chem (2014)

Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents

Por Rai, Ganesha, Thomas, Craig J., Leister, William, Maloney, David J.
Publicado em 2009

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

Por Dorjsuren, Dorjbal, Kim, Daemyung, Maloney, David J., Wilson, David M., Simeonov, Anton
Publicado em 2011

Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction

Por LeClair, Christopher A., Boxer, Matthew B., Thomas, Craig J., Maloney, David J.
Publicado em 2010

High-Throughput 1,536-Well Fluorescence Polarization Assays for α(1)-Acid Glycoprotein and Human Serum Albumin Binding

Por Yasgar, Adam, Furdas, Silviya D., Maloney, David J., Jadhav, Ajit, Jung, Manfred, Simeonov, Anton
Publicado em 2012

Structural Insight into Exosite Binding and Discovery of Novel Exosite Inhibitors of Botulinum Neurotoxin Serotype A Through in silico Screening

Por Hu, Xin, Legler, Patricia M., Southall, Noel, Maloney, David J., Simeonov, Anton, Jadhav, Ajit
Publicado em 2014

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

Por Dorjsuren, Dorjbal, Kim, Daemyung, Vyjayanti, Vaddadi N., Maloney, David J., Jadhav, Ajit, Wilson, David M., Simeonov, Anton
Publicado em 2012

Synthesis, Biological Evaluation and Structure-Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

Por Rai, Ganesha, Vyjayanti, Vaddadi N., Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Maloney, David J.
Publicado em 2012

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

Por Tersey, Sarah A., Bolanis, Esther, Holman, Theodore R., Maloney, David J., Nadler, Jerry L., Mirmira, Raghavendra G.
Publicado no Mol Endocrinol (2015)

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature

Por Li, Luowei, Shukla, Suneet, Lee, Andrew, Garfield, Susan H., Maloney, David J., Ambudkar, Suresh V., Yuspa, Stuart H.
Publicado em 2010

High throughput screen identifies cyclic nucleotide analogs that inhibit Prostatic acid phosphatase

Por McCoy, Eric S., Lea, Wendy A., Mott, Bryan T., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Zylka, Mark J.
Publicado em 2012

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Por Yamanaka, Kinrin, Dorjsuren, Dorjbal, Eoff, Robert L., Egli, Martin, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Lloyd, R. Stephen
Publicado em 2012

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

Por Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Publicado no Biochem J (2015)

Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency

Por Liang, Yu, Vogel, Jodi L., Arbuckle, Jesse H., Rai, Ganesha, Jadhav, Ajit, Simeonov, Anton, Maloney, David J., Kristie, Thomas M.
Publicado no Sci Transl Med (2013)

Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells

Por Chen, Junjun, Dexheimer, Thomas S., Ai, Yongxing, Liang, Qin, Villamil, Mark A., Inglese, James, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Zhuang, Zhihao
Publicado em 2011

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom Helicase

Por Rosenthal, Andrew S., Dexheimer, Thomas S., Gileadi, Opher, Nguyen, Giang H., Chu, Wai Kit, Hickson, Ian D., Jadhav, Ajit, Simeonov, Anton, Maloney, David J.
Publicado em 2013

A fluorescence-based high throughput assay for the determination of small molecule–human serum albumin protein binding

Por McCallum, Megan M., Pawlak, Alan J., Shadrick, William R., Simeonov, Anton, Jadhav, Ajit, Yasgar, Adam, Maloney, David J., Arnold, Leggy A.
Publicado em 2014

A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

Por Jameson, J. Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R.
Publicado em 2014

A parallel chemistry approach to identify novel nuclear receptor ligands based on the GW0742 scaffold

Por Teske, Kelly A., Rai, Ganesha, Nandhikonda, Premchendar, Sidhu, Preetpal S., Feleke, Belaynesh, Simeonov, Anton, Yasgar, Adam, Jadhav, Ajit, Maloney, David J., Arnold, Leggy A.
Publicado no ACS Comb Sci (2017)

Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease

Por Jadhav, Ajit, Ferreira, Rafaela S., Klumpp, Carleen, Mott, Bryan T., Austin, Christopher P., Inglese, James, Thomas, Craig J., Maloney, David J., Shoichet, Brian K., Simeonov, Anton
Publicado em 2010