Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contribute to resistance to various anticancer drugs, wh...

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Détails bibliographiques
Auteurs principaux: Dorjsuren, Dorjbal, Kim, Daemyung, Vyjayanti, Vaddadi N., Maloney, David J., Jadhav, Ajit, Wilson, David M., Simeonov, Anton
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479139/
https://ncbi.nlm.nih.gov/pubmed/23110144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047974
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