Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

The apurinic/apyrimidinic endonuclease 1 (APE1) is a protein central to the base excision DNA repair pathway and operates in the modulation of gene expression through redox-dependent and independent mechanisms. Aberrant expression and localization of APE1 in tumors are recurrent hallmarks of aggress...

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Publicado en:Mol Carcinog
Autores principales: Poletto, Mattia, Malfatti, Matilde C., Dorjsuren, Dorjbal, Scognamiglio, Pasqualina L., Marasco, Daniela, Vascotto, Carlo, Jadhav, Ajit, Maloney, David J., Wilson, David M., Simeonov, Anton, Tell, Gianluca
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600639/
https://ncbi.nlm.nih.gov/pubmed/25865359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22313
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