Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1

APE1 is the major nuclease for excising abasic (AP) sites and particular 3′-obstructive termini from DNA, and is an integral participant in the base excision repair (BER) pathway. BER capacity plays a prominent role in dictating responsiveness to agents that generate oxidative or alkylation DNA dama...

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Main Authors: Simeonov, Anton, Kulkarni, Avanti, Dorjsuren, Dorjbal, Jadhav, Ajit, Shen, Min, McNeill, Daniel R., Austin, Christopher P., Wilson, David M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685009/
https://ncbi.nlm.nih.gov/pubmed/19484131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005740
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