Reduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (APE1) Variants on Nucleosomes: IDENTIFICATION OF ACCESS RESIDUES

Non-coding apurinic/apyrimidinic (AP) sites are generated at high frequency in genomic DNA via spontaneous hydrolytic, damage-induced or enzyme-mediated base release. AP endonuclease 1 (APE1) is the predominant mammalian enzyme responsible for initiating removal of mutagenic and cytotoxic abasic les...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hinz, John M., Mao, Peng, McNeill, Daniel R., Wilson, David M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543664/
https://ncbi.nlm.nih.gov/pubmed/26134573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665547
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