Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes

Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in vivo DNA lesion. For repair, AP sites must be processed by 5′ AP endonucleases in initial stages of base repair. Human APE1 and bacterial Nfo...

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Main Authors: Tsutakawa, Susan E., Shin, David S., Mol, Clifford D., Izumi, Tadahide, Arvai, Andrew S., Mantha, Anil K., Szczesny, Bartosz, Ivanov, Ivaylo N., Hosfield, David J., Maiti, Buddhadev, Pique, Mike E., Frankel, Kenneth A., Hitomi, Kenichi, Cunningham, Richard P., Mitra, Sankar, Tainer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605660/
https://ncbi.nlm.nih.gov/pubmed/23355472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422774
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