Polyubiquitination of Apurinic/Apyrimidinic Endonuclease 1 by Parkin

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson’s disease (PD) associated gene, is an E3 ubiquitin ligase crucial for mitophagy. While DNA dam...

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Bibliographic Details
Published in:Mol Carcinog
Main Authors: Scott, Timothy L., Wicker, Christina A., Suganya, Rangaswamy, Dhar, Bithika, Pittman, Thomas, Horbinski, Craig, Izumi, Tadahide
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379662/
https://ncbi.nlm.nih.gov/pubmed/27148961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22495
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