A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Human DNA polymerase kappa (pol κ) is a translesion synthesis (TLS) polymerase that catalyzes TLS past various minor groove lesions including N (2)-dG linked acrolein- and polycyclic aromatic hydrocarbon-derived adducts, as well as N (2)-dG DNA–DNA interstrand cross-links introduced by the chemother...

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Detalhes bibliográficos
Main Authors: Yamanaka, Kinrin, Dorjsuren, Dorjbal, Eoff, Robert L., Egli, Martin, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Lloyd, R. Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466269/
https://ncbi.nlm.nih.gov/pubmed/23056190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045032
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