Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom Helicase

Human cells utilize a variety of complex DNA repair mechanisms in order to combat constant mutagenic and cytotoxic threats from both exogenous and endogenous sources. The RecQ family of DNA helicases, which includes Bloom helicase (BLM), plays an important function in DNA repair by unwinding complem...

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Detalhes bibliográficos
Main Authors: Rosenthal, Andrew S., Dexheimer, Thomas S., Gileadi, Opher, Nguyen, Giang H., Chu, Wai Kit, Hickson, Ian D., Jadhav, Ajit, Simeonov, Anton, Maloney, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824626/
https://ncbi.nlm.nih.gov/pubmed/24012121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.025
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