Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

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Библиографические подробности
Главные авторы: Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677093/
https://ncbi.nlm.nih.gov/pubmed/23665168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.03.012
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