Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

[Image: see text] DYRK kinases are involved in alternative pre-mRNA splicing as well as in neuropathological states such as Alzheimer's disease and Down syndrome. In this study, we present the design, synthesis, and biological evaluation of indirubins as DYRK inhibitors with enhanced selectivit...

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Detalhes bibliográficos
Main Authors: Myrianthopoulos, Vassilios, Kritsanida, Marina, Gaboriaud-Kolar, Nicolas, Magiatis, Prokopios, Ferandin, Yoan, Durieu, Emilie, Lozach, Olivier, Cappel, Daniel, Soundararajan, Meera, Filippakopoulos, Panagis, Sherman, Woody, Knapp, Stefan, Meijer, Laurent, Mikros, Emmanuel, Skaltsounis, Alexios-Leandros
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545483/
https://ncbi.nlm.nih.gov/pubmed/23336033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300207a
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