An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

BACKGROUND: In search of new antiparasitic agents for overcoming the limitations of current leishmaniasis chemotherapy, we have previously shown that 6-bromoindirubin-3'-oxime (6BIO) and several other 6-substituted analogues of indirubin, a naturally occurring bis-indole present in mollusks and...

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Библиографические подробности
Главные авторы: Efstathiou, Antonia, Gaboriaud-Kolar, Nicolas, Smirlis, Despina, Myrianthopoulos, Vassilios, Vougogiannopoulou, Konstantina, Alexandratos, Alexandros, Kritsanida, Marina, Mikros, Emmanuel, Soteriadou, Ketty, Skaltsounis, Alexios-Leandros
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039064/
https://ncbi.nlm.nih.gov/pubmed/24886176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-3305-7-234
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