Soluble 3′, 6-substituted indirubins with enhanced selectivity towards glycogen synthase kinase -3 alter circadian period

Glycogen synthase kinase -3 (GSK-3) is a key enzyme involved in numerous physiological events and in major diseases, such as Alzheimer's disease, diabetes, cardiac hypertrophy. Indirubins are bis-indoles which can be generated from various natural sources or chemically synthesized. While highly...

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Bibliografiset tiedot
Päätekijät: VOUGOGIANNOPOULOU, Konstantina, FERANDIN, Yoan, BETTAYEB, Karima, MYRIANTHOPOULOS, Vassilios, LOZACH, Olivier, FAN, Yunzhen, JOHNSON, Carl Hirschie, MAGIATIS, Prokopios, SKALTSOUNIS, Alexios-Leandros, MIKROS, Emmanuel, MEIJER, Laurent
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717725/
https://ncbi.nlm.nih.gov/pubmed/18816110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800648y
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