Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

[Image: see text] DYRK kinases are involved in alternative pre-mRNA splicing as well as in neuropathological states such as Alzheimer's disease and Down syndrome. In this study, we present the design, synthesis, and biological evaluation of indirubins as DYRK inhibitors with enhanced selectivit...

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Autores principales: Myrianthopoulos, Vassilios, Kritsanida, Marina, Gaboriaud-Kolar, Nicolas, Magiatis, Prokopios, Ferandin, Yoan, Durieu, Emilie, Lozach, Olivier, Cappel, Daniel, Soundararajan, Meera, Filippakopoulos, Panagis, Sherman, Woody, Knapp, Stefan, Meijer, Laurent, Mikros, Emmanuel, Skaltsounis, Alexios-Leandros
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2012
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545483/
https://ncbi.nlm.nih.gov/pubmed/23336033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300207a
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