Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

by Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J
Published in Br J Pharmacol (2017)

Wnt signaling in cancer: not a binary ON:OFF switch

by Flanagan, Dustin J., Vincan, Elizabeth, Phesse, Toby J.
Published in Cancer Res (2019)

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

by Flanagan, Dustin J., Austin, Chloe R., Vincan, Elizabeth, Phesse, Toby J.
Published in Genes (Basel) (2018)

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

by Flanagan, Dustin J., Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J., Vincan, Elizabeth
Published in Dis Model Mech (2017)

Intestinal epithelial-specific PTEN inactivation results in tumor formation

by Byun, Do-Sun, Ahmed, Naseem, Nasser, Shannon, Shin, Joongho, Al-Obaidi, Sheren, Goel, Sanjay, Corner, Georgia A., Wilson, Andrew J., Flanagan, Dustin J., Williams, David S., Augenlicht, Leonard H., Vincan, Elizabeth, Mariadason, John M.
Published 2011

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5(+) Stem Cells

by Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth
Published in Stem Cell Reports (2015)

Retrograde movements determine effective stem cell numbers in the intestine

by Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I.J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J.A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Published in Nature (2022)

Apc-mutant cells deploy Notum to bias clonal competition and drive cancer

by Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna, Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Yvonne Jones, E., Ristimäki, Ari, Leedham, Simon, Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.
Published in Nature (2021)

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

by Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.
Published in Nat Commun (2021)

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

by Knight, John R. P., Alexandrou, Constantinos, Skalka, George L., Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M., May-Wilson, Sebastian, Smith, Ewan M., Najumudeen, Arafath K., Gilroy, Kathryn, Ridgway, Rachel A., Flanagan, Dustin J., Smith, Rachael C. L., McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D., Jackstadt, Rene, Waldron, Joseph A., Campbell, Andrew D., Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M., Sonenberg, Nahum, Proud, Christopher G., Jones, Neil P., Swarbrick, Martin E., McKinnon, Heather J., Faller, William J., Le Quesne, John, Edwards, Joanne, Willis, Anne E., Bushell, Martin, Sansom, Owen J.
Published in Cancer Discov (2021)