MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

KRAS-mutant colorectal cancers (CRC) are resistant to therapeutics, presenting a significant problem for ~40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant CRC. Using Kras-mutant mouse models and mouse- and patient-derived organoids...

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Publicado no:Cancer Discov
Main Authors: Knight, John R. P., Alexandrou, Constantinos, Skalka, George L., Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M., May-Wilson, Sebastian, Smith, Ewan M., Najumudeen, Arafath K., Gilroy, Kathryn, Ridgway, Rachel A., Flanagan, Dustin J., Smith, Rachael C. L., McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D., Jackstadt, Rene, Waldron, Joseph A., Campbell, Andrew D., Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M., Sonenberg, Nahum, Proud, Christopher G., Jones, Neil P., Swarbrick, Martin E., McKinnon, Heather J., Faller, William J., Le Quesne, John, Edwards, Joanne, Willis, Anne E., Bushell, Martin, Sansom, Owen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611341/
https://ncbi.nlm.nih.gov/pubmed/33328217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0652
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