Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

Arsenic trioxide (As(2)O(3)) is a potent inducer of apoptosis of malignant cells in vitro and in vivo, but the precise mechanisms by which it mediates such effects are not well defined. We provide evidence that As(2)O(3) induces phosphorylation/activation of the MAPK signal-integrating kinases (Mnks...

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Detalhes bibliográficos
Main Authors: Dolniak, Blazej, Katsoulidis, Efstratios, Carayol, Nathalie, Altman, Jessica K., Redig, Amanda J., Tallman, Martin S., Ueda, Takeshi, Watanabe-Fukunaga, Rie, Fukunaga, Rikiro, Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335346/
https://ncbi.nlm.nih.gov/pubmed/18299328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708816200
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