Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

Arsenic trioxide (As(2)O(3)) is a potent inducer of apoptosis of malignant cells in vitro and in vivo, but the precise mechanisms by which it mediates such effects are not well defined. We provide evidence that As(2)O(3) induces phosphorylation/activation of the MAPK signal-integrating kinases (Mnks...

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Bibliografische gegevens
Hoofdauteurs: Dolniak, Blazej, Katsoulidis, Efstratios, Carayol, Nathalie, Altman, Jessica K., Redig, Amanda J., Tallman, Martin S., Ueda, Takeshi, Watanabe-Fukunaga, Rie, Fukunaga, Rikiro, Platanias, Leonidas C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
Onderwerpen:
Mechanisms of Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335346/
https://ncbi.nlm.nih.gov/pubmed/18299328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708816200
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