Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide

Arsenic trioxide (As(2)O(3)) exhibits potent antitumor effects in vitro and in vivo, but the precise mechanisms by which it generates such responses are not well understood. We provide evidence that As(2)O(3) is a potent inducer of autophagy in leukemia cells. Such induction of autophagy by As(2)O(3...

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Autors principals: Goussetis, Dennis J., Altman, Jessica K., Glaser, Heather, McNeer, Jennifer L., Tallman, Martin S., Platanias, Leonidas C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943259/
https://ncbi.nlm.nih.gov/pubmed/20656687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090530
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