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Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide
Arsenic trioxide (As(2)O(3)) exhibits potent antitumor effects in vitro and in vivo, but the precise mechanisms by which it generates such responses are not well understood. We provide evidence that As(2)O(3) is a potent inducer of autophagy in leukemia cells. Such induction of autophagy by As(2)O(3...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943259/ https://ncbi.nlm.nih.gov/pubmed/20656687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090530 |
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