Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses

Mnk kinases are downstream effectors of mitogen-activated protein kinase pathways and mediate phosphorylation of the eukaryotic initiation factor (eIF4E), a protein that plays a key role in the regulation of mRNA translation and is up-regulated in acute myeloid leukemia (AML). We determined the effe...

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Bibliographic Details
Main Authors: Altman, Jessica K., Glaser, Heather, Sassano, Antonella, Joshi, Sonali, Ueda, Takeshi, Watanabe-Fukunaga, Rie, Fukunaga, Rikiro, Tallman, Martin S., Platanias, Leonidas C.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981388/
https://ncbi.nlm.nih.gov/pubmed/20664001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064642
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