Essential Role for Mnk Kinases in Type II Interferon (IFNγ) Signaling and Its Suppressive Effects on Normal Hematopoiesis

IFNγ exhibits potent antitumor effects and plays important roles in the innate immunity against cancer. However, the mechanisms accounting for the antiproliferative effects of IFNγ still remain to be elucidated. We examined the role of Mnk1 (MAPK-interacting protein kinase 1) in IFNγ signaling. Our...

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Main Authors: Joshi, Sonali, Sharma, Bhumika, Kaur, Surinder, Majchrzak, Beata, Ueda, Takeshi, Fukunaga, Rikiro, Verma, Amit K., Fish, Eleanor N., Platanias, Leonidas C.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057839/
https://ncbi.nlm.nih.gov/pubmed/21149447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197921
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