Essential Role for Mnk Kinases in Type II Interferon (IFNγ) Signaling and Its Suppressive Effects on Normal Hematopoiesis

IFNγ exhibits potent antitumor effects and plays important roles in the innate immunity against cancer. However, the mechanisms accounting for the antiproliferative effects of IFNγ still remain to be elucidated. We examined the role of Mnk1 (MAPK-interacting protein kinase 1) in IFNγ signaling. Our...

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Main Authors: Joshi, Sonali, Sharma, Bhumika, Kaur, Surinder, Majchrzak, Beata, Ueda, Takeshi, Fukunaga, Rikiro, Verma, Amit K., Fish, Eleanor N., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057839/
https://ncbi.nlm.nih.gov/pubmed/21149447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197921
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