Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells

The interferons (IFNs) are cytokines that play key roles in host defense against viral infections and immune surveillance against cancer. We report that BCR-ABL transformation of hematopoietic cells results in suppression of IFN-dependent responses, including transcription of IFN-inducible genes and...

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Autori principali: Katsoulidis, Efstratios, Sassano, Antonella, Majchrzak-Kita, Beata, Carayol, Nathalie, Yoon, Patrick, Jordan, Alison, Druker, Brian J., Fish, Eleanor N., Platanias, Leonidas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447623/
https://ncbi.nlm.nih.gov/pubmed/18287094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706816200
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