Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Por Druker, Brian J., Lydon, Nicholas B.
Publicado em 2000

Applying the discovery of the Philadelphia chromosome

Por Sherbenou, Daniel W., Druker, Brian J.
Publicado em 2007

Kinase Inhibitor Therapy in CML: It's What's Inside That Counts

Por Eide, Christopher A., Druker, Brian J., O'Hare, Thomas
Publicado em 2013

Inhibition of p38 MAPK Suppresses Inflammatory Cytokine Induction by Etoposide, 5-Fluorouracil, and Doxorubicin without Affecting Tumoricidal Activity

Por Elsea, Collin R., Roberts, Daniel A., Druker, Brian J., Wood, Lisa J.
Publicado em 2008

Integrating in vitro sensitivity and dose-response slope is predictive of clinical response to ABL kinase inhibitors in chronic myeloid leukemia

Por Vainstein, Vladimir, Eide, Christopher A., O’Hare, Thomas, Shukron, Ofir, Druker, Brian J.
Publicado em 2013

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Por Corbin, Amie S., Agarwal, Anupriya, Loriaux, Marc, Cortes, Jorge, Deininger, Michael W., Druker, Brian J.
Publicado em 2010

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Por Corbin, Amie S., Agarwal, Anupriya, Loriaux, Marc, Cortes, Jorge, Deininger, Michael W., Druker, Brian J.
Publicado em 2011

In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia

Por Glover, Jason M, Loriaux, Marc, Tyner, Jeffrey W, Druker, Brian J, Chang, Bill H
Publicado em 2012

An Intron-Derived Insertion/Truncation Mutation in the BCR-ABL Kinase Domain in Chronic Myeloid Leukemia Patients Undergoing Kinase Inhibitor Therapy

Por Laudadio, Jennifer, Deininger, Michael W.N., Mauro, Michael J., Druker, Brian J., Press, Richard D.
Publicado em 2008

Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway

Por Carayol, Nathalie, Katsoulidis, Efstratios, Sassano, Antonella, Altman, Jessica K., Druker, Brian J., Platanias, Leonidas C.
Publicado em 2008

Mouse model of intrahepatic cholangiocarcinoma validates FIG–ROS as a potent fusion oncogene and therapeutic target

Por Saborowski, Anna, Saborowski, Michael, Davare, Monika A., Druker, Brian J., Klimstra, David S., Lowe, Scott W.
Publicado em 2013

PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma

Por Aslam, M. Imran, Abraham, Jinu, Mansoor, Atiya, Druker, Brian J., Tyner, Jeffrey W., Keller, Charles
Publicado em 2014

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl

Por Chen, Jing, Yu, Wen-Mei, Daino, Hanako, Broxmeyer, Hal E., Druker, Brian J., Qu, Cheng-Kui
Publicado em 2007

A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

Por Qiu, Xiaoxue, Guo, Guijie, Chen, Ke, Kashiwada, Masaki, Druker, Brian J, Rothman, Paul B, Chen, Ji-Long
Publicado em 2012

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Por Watanabe-Smith, Kevin, Tognon, Cristina, Tyner, Jeffrey W., Meijerink, Jules P.P., Druker, Brian J., Agarwal, Anupriya
Publicado no Leukemia (2016)

Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise

Por Ross, Rebecca L., Jones, Kim D., Bennett, Robert M., Ward, Rachel L., Druker, Brian J., Wood, Lisa J.
Publicado em 2010

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Por Johnson, Kara J., Griswold, Ian J., O'Hare, Thomas, Corbin, Amie S., Loriaux, Marc, Deininger, Michael W., Druker, Brian J.
Publicado em 2009

Acute dasatinib exposure commits Bcr-Abl–dependent cells to apoptosis

Por Snead, Jennifer L., O'Hare, Thomas, Adrian, Lauren T., Eide, Christopher A., Lange, Thoralf, Druker, Brian J., Deininger, Michael W.
Publicado em 2009

Crosstalk between ROR1 and the pre-B-Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Por Bicocca, Vincent T., Chang, Bill H., Masouleh, Behzad Kharabi, Muschen, Markus, Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
Publicado em 2012

Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerizatio...

Por Maxson, Julia E., Luty, Samuel B., MacManiman, Jason D., Abel, Melissa L., Druker, Brian J., Tyner, Jeffrey W.
Publicado em 2014