A Requirement for SOCS-1 and SOCS-3 Phosphorylation in Bcr-Abl-Induced Tumorigenesis

Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3) are inhibitors of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT) pathway and function in a negative feedback loop during cytokine signaling. Abl transformation is associated with constitutive act...

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Autors principals: Qiu, Xiaoxue, Guo, Guijie, Chen, Ke, Kashiwada, Masaki, Druker, Brian J, Rothman, Paul B, Chen, Ji-Long
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394197/
https://ncbi.nlm.nih.gov/pubmed/22787435
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