A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis

CDKN3 (cyclin-dependent kinase inhibitor 3), a dual specificity protein phosphatase, dephosphorylates cyclin-dependent kinases (CDKs) and thus functions as a key negative regulator of cell cycle progression. Deregulation or mutations of CDNK3 have been implicated in various cancers. However, the rol...

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Autors principals: Chen, Qinghuang, Chen, Ke, Guo, Guijie, Li, Fang, Chen, Chao, Wang, Song, Nalepa, Grzegorz, Huang, Shile, Chen, Ji-Long
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216094/
https://ncbi.nlm.nih.gov/pubmed/25360622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111611
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