Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity

Protein kinase R (PKR) is a vital component of host innate immunity against viral infection. However, the mechanism underlying inactivation of PKR by influenza A virus (IAV) remains elusive. Here, we found that vault RNAs (vtRNAs) were greatly induced in A549 cells and mouse lungs after infection wit...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Li, Fang, Chen, Yuhai, Zhang, Zhaoyuan, Ouyang, Jing, Wang, Yi, Yan, Ruoxiang, Huang, Shile, Gao, George Fu, Guo, Guijie, Chen, Ji-Long
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666359/
https://ncbi.nlm.nih.gov/pubmed/26490959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1078
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