Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerization

Eitemau Tebyg

• The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition
  gan: Fleischman, Angela G., et al.
  Cyhoeddwyd: (2013)
• The Colony Stimulating Factor 3 Receptor T640N mutation is oncogenic, sensitive to JAK inhibition, and mimics T618I
  gan: Maxson, Julia E., et al.
  Cyhoeddwyd: (2015)
• Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation
  gan: Zhang, Haijiao, et al.
  Cyhoeddwyd: (2018)
• Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia
  gan: Dao, Kim-Hien T., et al.
  Cyhoeddwyd: (2014)
• CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia
  gan: Pardanani, A, et al.
  Cyhoeddwyd: (2013)